Nutraceuticals for Cancer Risk

It is well known that cancer is not only related to heredity, but also to lifestyle, including diet and environmental exposure. Before you choose nutritional supplements to deal with the risk of cancer, you should know that the pathogenesis of cancer is very complex, and we cannot expect to achieve the purpose of preventing and fighting cancer through simple methods.

Here, we help you understand the current research overview and progress of nutritional supplements in cancer risk. Protheragen reminds you that the anti-cancer effect of nutraceuticals can only be used as an auxiliary means to prevent cancer risk, and we also provide the high-quality nutraceuticals you need.

Active Ingredients for Cancer Risk

Numerous studies have identified many nutraceuticals with different chemical structures that fight cancer. The figure below shows the common source of some nutraceuticals known to have cancer chemopreventive properties and their chemical structures. [1] Tripathi et al. reported the chemotherapeutic value of nutraceuticals in cancer. Most of their evidence for cancer prevention was in the presence of phytochemicals, fats, flavonoids, phytoestrogens, isoflavones, genestein, curcumin, capsaicin, epigallocatechin-3-gallate, gingerol, tomato observed in animal studies of erythrocytes, antioxidants, vitamins and minerals. [2]

Mechanisms of Nutraceuticals for Cancer Prevention

Nutraceuticals may act as cancer prevention mechanisms by reducing cellular damage, delaying apoptosis (cell death), DNA interactions, reducing necrosis, cell proliferation, signaling, and maintaining metabolic integrity in cancer tissues. [3] Selected anticancer modes of action by cancer type and nutrient classification are summarized in the table below.[4]

Related Research Information

Polyphenols

Polyphenols are secondary plant metabolites containing one or more hydroxyl groups attached to a benzene ring in their structure. Among the polyphenolic compounds, the group of phenolic acids, flavonoids, stilbene and curcumin are the most important because of their ability to block the initiation of carcinogenic processes and inhibit cancer progression. [5] The main process of phenolic compounds promoting apoptosis is shown in the figure below [6].

Vitamins and minerals

Several independent studies have shown that trace elements such as vitamins A, C, E and selenium protect against cancer. Supplementation with micronutrients as an adjuvant for cancer patients may be helpful. Ascorbic acid acts as an electron donor in redox reactions, and substantial evidence supports the notion that oxidative stress plays a major role in the mechanism of ascorbate toxicity in tumor cells. [5]

References

1. Yogeshwer Shukla. (2011). "Combinatorial strategies employing nutraceuticals for cancer development," Ann. N.Y. Acad. Sci. 1229, 162–175.
2. Yamini B Tripathi. (2005). "Nutraceuticals and cancer management," Front. Biosci. 10(2), 1607–1618.
3. Pramod Kumar. (2019). "Chapter 12 - Role of Food and Nutrition in Cancer," The Role of Functional Food Security in Global Health, 193-203.
4. Mudhi AlAli. (2021). "Nutraceuticals: Transformation of Conventional Foods into Health Promoters/Disease Preventers and Safety Considerations," Molecules 26(9), 2540.
5. Elia Ranzato. (2014). "Role of Nutraceuticals in Cancer Therapy," Journal of Food Research 3(4), 1927-0887.
6. Haroon Khan. (2021). "Advances and challenges in cancer treatment and nutraceutical prevention: the possible role of dietary phenols in BRCA regulation," Phytochem Rev. 826.

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