Glucosamine

Uses and Effectiveness

Forms

• Glucosamine hydrochloride
• Glucosamine sulfate
• N-Ethyl Glucosamine

Uses

• Improve joint health and osteoarthritis (OA)
• Relieve joint pain, rheumatoid arthritis, multiple sclerosis
• Promotes digestion and relieves inflammatory bowel disease
• Reduce inflammation and help reverse autoimmune responses

Effectiveness

• The use of glucosamine remains widespread, despite conflicting results from numerous controlled trials of glucosamine. We encourage patients to have an open discussion with their physicians to fully understand the controversies surrounding the effectiveness of supplements.
• OA is a common form of arthritis that is often associated with severe disability and impaired quality of life. A study published in the Cochrane Database of Systematic Reviews reviewed randomized controlled trials (RCTs) evaluating the efficacy and toxicity of glucosamine in OA. Studies evaluating Rotta formulations show that glucosamine is superior to placebo in treating pain and dysfunction caused by symptomatic OA.[1]

Precautions

The following are key points about taking glucosamine for consumers' reference only. For your health, please consult your doctor before taking it.

• Contraindications
  Allergy to shellfish
  Using warfarin or diabetes medication
  Pregnancy and breastfeeding: keep safe and avoid use.
  Glaucoma: glucosamine may increase pressure in the eye and may make glaucoma worse.
  Asthma: glucosamine might make asthma worse.
• Interactions
  Diabetes medications: reduced effectiveness (theoretical)
  Cancer Drugs (Topoisomerase II Inhibitors): block cancer drugs from working
  Warfarin (Coumadin): increased risk of severe bruising and bleeding
• Asthma
  Use of warfarin or diabetes medications

Related Research Information

References

1. Tanveer Towheed. (2005). "Glucosamine therapy for treating osteoarthritis," Cochrane Database of Systematic Reviews 2. Art. No.: CD002946.
2. H Murad. (2001). "The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneous aging: a preliminary study," Journal of Dermatological Treatment 12, 47–51.
3. Hao Ma. (2019). "Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank," British Medical Journal 365, l1628.

※ These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.